Ovarian Cancer Australia was founded by people directly affected by ovarian cancer who wanted to raise awareness of the disease and support those who had been affected.

This group included Nicole Livingstone OAM and her sister Karen Livingstone who lost their mother and aunt to the disease; Simon Lee, whose wife Sheila had been the first Australian ovarian cancer campaigner prior to her death in 2001; actress and comedian Lynda Gibson who was diagnosed in 2000 and subsequently lost her battle in 2004.

Ovarian Cancer Australia was incorporated in July 2001. It was known as OvCa Australia, the National Ovarian Cancer Network, until changing its name to Ovarian Cancer Australia in 2008.